CBS Seminar: Laura Andreae- Cell-type specific synaptic alterations in mouse models for ASD

Bio: Laura Andreae studied medicine at Cambridge and UCL, and practised as a doctor for a few years before seeing the light! She did her PhD with Andrew Lumsden in developmental neurobiology at King's College London followed by a postdoc with Tim Bliss working on LTP and plasticity at the NIMR in Mill Hill, and with Juan Burrone on synaptic vesicle cycling at King's. She set up her own lab at King's at the end of 2013. Her lab works on synapse and circuit development in health and in the context of neurodevelopmental disorders.

Abstract: Genetic studies have identified many genes as conferring increased risk for autism, but how these genetic alterations lead to phenotypic changes is not understood. We are interested in identifying and understanding cellular phenotypes, in the hope of finding potential mechanistic convergence and perhaps eventually therapeutic targets. Autism risk genes tend to broadly fall into two categories: transcriptional control and synaptic. We have investigated mouse models with mutations in each of these categories, and focused on identifying changes to the balance between excitatory and inhibitory synapses in prefrontal cortex. 

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